Sorafenib (Free base)

A tyrosine kinase inhibitor

Cat. No.: AUR11016

CAS Number: 284461-73-0

Documents:

SizePrice

5 g

$ 185

Tags Sorafenib BAY 43-9006 475207-59-1 475207591 Tyrosine kinase inhibitor Auroamedbiochem

Alternate Names

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; BAY 43-9006; Nexavar

Appearance

White to off-white solid

Formulation

N/A

CAS Number

284461-73-0

Molecular Formula

C₂₁H₁₆ClF₃N₄O₃

Molecular Weight

464.83

Purity

≥98% by HPLC

Solubility

DMSO (~2 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

MFCD06411450

PubChem CID

216239

SMILES

CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChI

InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)

InChI key

MLDQJTXFUGDVEO-UHFFFAOYSA-N

Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-β and their associated signaling cascades.

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