LIM Kinase Inhibitor I, LIMKi 3

A LIM kinase inhibitor

Cat. No.: AUR10542

CAS Number: 1338247-35-0

Documents:

SizePrice

10 mg

$ 215

Tags LIM Kinase Inhibitor I LIMKi 3 BMS-5 BMS5 LIM kinase inhibitor CAS#1338247-35-0 1338247-35-0 Auroramedbiochem

Alternate Names

N-[5-[2-(2,6-dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methylpropanamide; BMS-5

Appearance

Beige solid

Formulation

N/A

CAS Number

1338247-35-0

Molecular Formula

C17H14Cl2F2N4OS

Molecular Weight

431.29

Purity

≥95% by HPLC

Solubility

DMSO (100 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2 to +8 ◦C

Shipping Condition

Shelf life

24 months

MDL number

MFCD17019327

PubChem CID

56965901

SMILES

CC(C)C(=O)NC1=NC=C(S1)C2=CC(=NN2C3=C(C=CC=C3Cl)Cl)C(F)F

InChI

InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26)

InChI key

IVUGBSGLHRJSSP-UHFFFAOYSA-N

LIMKi 3 is a cell-permeable compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~ 1 µM in A549 and MDA-MB-231 cultures) without affecting tubulin polymerization or inducing cytotoxicity (EC50 >10 µM in A549 proliferation and colony formation assays).

Shopping Cart