GSK-872

A selective inhibitor of RIPK3

Cat. No.: AUR10863

CAS Number: 1346546-69-7

Documents:

SizePrice

100 mg

$ 975

Tags GSK-872 GSK872 RIPK3 inhibitor CAS#1346546-69-7 1346546-69-7 AuroraMedbiochem

Alternate Names

N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine; RIPK3 Inhibitor

Appearance

Yellow solid

Formulation

N/A

CAS Number

1346546-69-7

Molecular Formula

C₁₉H₁₇N₃O₂S₂

Molecular Weight

383.48

Purity

≥98% by HPLC

Solubility

DMSO ( 100 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

gel pack

Shelf life

24 months

MDL number

N/A

PubChem CID

155971189

SMILES

CC(C)S(C1=CC(C(NC2=CC=C(SC=N3)C3=C2)=CC=N4)=C4C=C1)(=O)=O

InChI

InChI=1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)

InChI key

ZCDBTQNFAPKACC-UHFFFAOYSA-N

GSK-872 is an inhibitor of receptor-interacting protein kinase 3 (RIPK3). It is selective for RIPK3, having >1,000-fold selectivity over 300 kinases in a fluorescence polarization assay at a concentration of 1 μM. GSK872 inhibits TNF- and virus-induced necrosis in 3T3-SA fibroblasts.