DAPK Inhibitor

A DAPK inhibitor

Cat. No.: AUR10292

CAS Number: 315694-89-4

Documents:

SizePrice

10 mg

$ 115

Tags DAPK inhibitor TC-DAPK 6 CAS#315694-89-4 315694-89-4 Auroramedbiochem

Alternate Names

(4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one

Appearance

Off-white solid

Formulation

N/A

CAS Number

315694-89-4

Molecular Formula

C17H12N2O2

Molecular Weight

276.3

Purity

>95% by LCMS

Solubility

DMSO (25 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2°C to +8°C

Shipping Condition

Shelf life

24 months

MDL number

N/A

PubChem CID

5676111

SMILES

C1=CC=C(C=C1)C=CC2=NC(=CC3=CN=CC=C3)C(=O)O2

InChI

InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11+

InChI key

GFGMISOSPOPSHN-QCTDOKRBSA-N

DAPK inhibitor is a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 µM ATP), while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 µM.