CRAC Channel Inhibitor, BTP2

A potent inhibitor of CRAC channels

Cat. No.: AUR10222

CAS Number: 223499-30-7

Documents:

SizePrice

25 mg

$ 425

Tags BTP2 CARC channel inhibitor 223499-30-7 CAS#223499-30-7 auroramedbiochem

Alternate Names

N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide; YM-58483

Appearance

White solid

Formulation

N/A

CAS Number

223499-30-7

Molecular Formula

C15H9F6N5OS

Molecular Weight

421.32

Purity

≥98% by HPLC

Solubility

DMSO (5 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2°C to +8°C

Shipping Condition

Shelf life

24 months

MDL number

MFCD00220976

PubChem CID

2455

SMILES

CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F

InChI

InChI=1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)

InChI key

XPRZIORDEVHURQ-UHFFFAOYSA-N

BTP2 is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM).

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