Bosutinib (SKI-606)

A tyrosine kinase inhibitor

Cat. No.: AUR11299

CAS Number: 380843-75-4

Documents:

SizePrice

1 g

$ 475

Tags Bosutinib SKI-606 380843-75-4 380843754 tyrosine kinase inhibitor Auroramedbiochem

Alternate Names

4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; SKI-606

Appearance

White to off-white solid

Formulation

N/A

CAS Number

380843-75-4

Molecular Formula

C₂₆H₂₉Cl₂N₅O₃

Molecular Weight

530.45

Purity

≥98% by HPLC

Solubility

DMSO (30 mg/ml) or EtOH (10 mg/ml)

Handling

Protect from light and moisture

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

Shelf life

24months

MDL number

MFCD07367846

PubChem CID

5328940

SMILES

CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC

InChI

InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)

InChI key

UBPYILGKFZZVDX-UHFFFAOYSA-N

Bosutinib (SKI-606) is a novel tyrosine kinase inhibitor. Bosutinib can overcome not only Bcr-Abl-dependent mechanisms of resistance, but also those that are Bcr-Abl-independent. It is used to treat patients with chronic myelogenous leukemia (CML) who demonstrate resistance to Imatinib or develop resistance during treatment.

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