BMP-2 Signaling Enhancer, A01

A Smurf1 E3 ubiquitin ligase inhibitor

Cat. No.: AUR11298

CAS Number: 1007647-73-5

Documents:

SizePrice

50 mg

$ 725

Tags A01 Smurf1 E3 ubiquitin ligase inhibitor CAS#1007647-73-5 1007647-73-5 Auroramedbiochem

Alternate Names

[4-[4-chloro-3-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]-[4-(5-methylpyrazol-1-yl)phenyl]methanone; A01

Appearance

Yellowish-white Solid

Formulation

N/A

CAS Number

1007647-73-5

Molecular Formula

C22H20ClF3N4O3S

Molecular Weight

512.93

Purity

>97% by LCMS

Solubility

DMSO (50 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

+2°C to +8°C

Shipping Condition

Shelf life

24 months

MDL number

MFCD09320899

PubChem CID

17555704

SMILES

CC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F

InChI

InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3

InChI key

QFYLTUDRXBNZFQ-UHFFFAOYSA-N

A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.

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