ABT-888

A potent PARP inhibitor

Cat. No.: AUR10032

CAS Number: 912445-05-7

Documents:

SizePrice

100 mg

$ 675

Tags ABT-888 ABT888 PARP inhibitor Auroramedbiochem 912445-05-7 912445057

Alternate Names

2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride

Appearance

Off-white solid

Formulation

N/A

CAS Number

912445-05-7

Molecular Formula

C₁₃H₁₆N₄O.2HCl

Molecular Weight

317.21

Purity

³98% by HPLC

Solubility

DMSO (>30 mg/ml)

Handling

Protect from air and light

Country of origin

USA

Storage temperature

-20°C

Shipping Condition

Shelf life

24months

MDL number

MFCD16661206

PubChem CID

45480520

SMILES

CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N.Cl.Cl

InChI

InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1

InChI key

DSBSVDCHFMEYBX-FFXKMJQXSA-N

Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.